[Is it justifiable to administrate vitamin A, E and D for 6 months in the premature infants?]. / Est-il légitime d'administrer des vitamines liposolubles (A, E et D) chez le prématuré pendant 6 mois?
Arch Pediatr
; 14(12): 1408-12, 2007 Dec.
Article
en Fr
| MEDLINE
| ID: mdl-17964126
ABSTRACT
UNLABELLED Information on the vitamin A and E nutritional status in preterm infants is scarce. POPULATION AND METHODS:
In the present prospective and longitudinal study, we measured the plasma concentrations of vitamins A, E, D and of retinol binding protein (RBP) in preterm infants (32-34 weeks of gestation) at birth, and verified whether oral supplementation with these 3 vitamins for 1, 3 and 6 months affected their plasma concentrations. The 17 consecutively recruited premature infants received daily 3000 IU of vitamin A, 5 mg of vitamin E and 1000 IU of vitamin D.RESULTS:
At birth, premature infants exhibited a low plasma concentrations of vitamin A (0.66 [0.41-0.96]) micromol/l, vitamin E (8.1 [4.2-16.9] micromol/l), RBP (0.45 [0.22-0.71] micromol/l) and 25 hydroxyvitamine D (25 OHD) (20 [20-40] nmol/l). Plasma vitamin A, E , D and RBP concentrations increased with time, but vitamin A at 1, 3 and 6 months did not attain values considered normal in term infants or adolescents. At 6 months, the plasma 25 OHD was at 92 (71-116) nmol/l, a concentration considered normal and non-toxic.CONCLUSION:
We recommend to increase oral administration of vitamin A to 5000 IU/day, at least for the first month of life and, thereafter to administer 3000 IU for 5 months. As for vitamin E and vitamin D, the doses used in this study are sufficient but should be administered for 6 months.
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Base de datos:
MEDLINE
Asunto principal:
Vitamina A
/
Vitamina D
/
Vitamina E
/
Recien Nacido Prematuro
Tipo de estudio:
Observational_studies
Límite:
Humans
/
Infant
/
Newborn
Idioma:
Fr
Revista:
Arch Pediatr
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia