Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases.
Amino Acids
; 35(1): 29-36, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18008028
ABSTRACT
Advanced glycation end-products (AGEs) are formed from the so-called Amadori products by rearrangement followed by other reactions giving rise to compounds bound irreversibly. The structure of some of them is shown and the mechanism of formation is described. Several AGE binding molecules (Receptors for AGE, RAGE) are known and it is thought that many of the effects caused by AGEs are mediated by RAGE. Some of these were shown to be toxic, and called TAGE. The mechanism of detoxification of glyoxal and methylglyoxal by the glyoxalase system is described and also the possibility to eliminate glycated proteins by deglycation enzymes. Compounds able to inhibit AGEs formation are also taken into consideration.
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Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Receptores Inmunológicos
/
Productos Finales de Glicación Avanzada
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Amino Acids
Asunto de la revista:
BIOQUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Italia