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Antioxidant enzyme immunoreactivity in rat von Ebner gland after nickel treatment.
Shiraishi, Mie; Doi, Yoshiaki; Kayashima, Kotaro; Fujimoto, Sunao.
Afiliación
  • Shiraishi M; Graduate School of Health and Nutritional Sciences, Nakamura Gakuen University, Jonan-ku, Fukuoka 814-0104, Japan.
Med Mol Morphol ; 41(1): 44-52, 2008 Mar.
Article en En | MEDLINE | ID: mdl-18470680
Our study was designed to clarify the role of antioxidant enzymes in the rat von Ebner gland during acute nickel toxicity. After treatment with nickel acetate, we monitored ultrastructural alterations in acinar and ductal cells, immunohistochemical staining for glutathione peroxidase (GPx) and glutathione S-transferases (GST mu and GST pi), and immunoreactivity for malondialdehyde (MDA). Immunoreactivity for MDA was present only in the acinar cells, and it was enhanced at 3 h after Ni treatment. In contrast, immunoreactivities for GPx and GSTs did not change in acinar cells but significantly increased in ductal cells after Ni treatment. Cytoplasmic vacuoles increased in acinar cells at 3 h after Ni treatment, but they almost completely disappeared at 24 h. No morphological changes were observed in taste bud cells from Ni-treated rats. Because lipid peroxidation, as monitored by immunoreactivity for MDA, was only transiently increased in the acinar cells, the enhanced antioxidant enzyme immunoreactivity in ductal cells of the von Ebner gland plays a crucial role in the self-defense system against nickel toxicity in the rat oral cavity.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Glándulas de von Ebner / Níquel / Antioxidantes Límite: Animals Idioma: En Revista: Med Mol Morphol Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2008 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Glándulas de von Ebner / Níquel / Antioxidantes Límite: Animals Idioma: En Revista: Med Mol Morphol Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2008 Tipo del documento: Article País de afiliación: Japón