[Two female siblings with childhood-onset systemic lupus erythematosus].
Nihon Rinsho Meneki Gakkai Kaishi
; 31(3): 172-7, 2008 Jun.
Article
en Ja
| MEDLINE
| ID: mdl-18587228
ABSTRACT
We herein report two female siblings with childhood-onset Systemic Lupus Erythematosus (SLE) who developed membranous lupus nephritis. The children were diagnosed as having SLE in reverse birth order at ages 11 and 14 years. Younger sister's initial symptom was edema and laboratory findings indicated proteinuria, hypocomplementemia and positive ANA/anti-dsDNA antibody. She was diagnosed as being SLE with membranous lupus nephritis based on International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification. Elder sister manifested general fatigue and edema twelve months after her sister. Laboratory findings showed proteinuria, hypocomplementemia, and positive ANA/anti-dsDNA antibody. A renal biopsy revealed mixed form of mesangial proliferative glomerulonephritis and membranous nephritis. Moreover, both of them were complicated with secondary Sjögren's syndrome. HLA typing was performed and the siblings were noted to have the same haplotype; A(*)0207, A(*)2402, B(*)4601, B(*)5201, B(*)5201, Cw(*)0102, Cw(*)1202, DRB1(*)0101, DRB1(*)0803.
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Base de datos:
MEDLINE
Asunto principal:
Lupus Eritematoso Sistémico
Límite:
Adolescent
/
Child
/
Female
/
Humans
Idioma:
Ja
Revista:
Nihon Rinsho Meneki Gakkai Kaishi
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón