Temporary sutureless amniotic membrane patch for acute alkaline burns.
Arch Ophthalmol
; 126(8): 1059-66, 2008 Aug.
Article
en En
| MEDLINE
| ID: mdl-18695099
ABSTRACT
OBJECTIVE:
To evaluate the clinical outcome of a new sutureless approach for a temporary amniotic membrane patch (ProKera; Bio-Tissue, Inc, Miami, Florida) in eyes with acute burns.METHODS:
Retrospective review of 5 eyes of 5 patients with grades I to III acute alkaline burns, receiving ProKera insertion within 8 days of injury.RESULTS:
These eyes had either total (2 cases) or extensive (60%-75%, 3 cases) corneal epithelial defects with limbal (120 degrees -360 degrees ) and conjunctival (30%-60%) epithelial defects. ProKera was inserted within a mean (SD) of 3.7 (3.1) days after burn and repeated 1 to 3 times for 3 cases. Conjunctival defects reepithelialized in 8.2 (5) days (range, 5-17 days), while limbal and corneal defects healed in 13.6 (8.3) days (range, 5-25 days). The latter was completed with circumferential closure of limbal defects followed by centripetal healing of corneal defects. In 3 eyes, early peripheral corneal neovascularization was followed by marked regression on completion of healing. During 16.8 (10.8) months of follow-up, all eyes retained a stable surface with improved corneal clarity, and without limbal deficiency or symblepharon.CONCLUSION:
This sutureless application of an amniotic membrane patch allows for early delivery of its biologic actions, which may help preserve remaining limbal stem cells for rapid expansion and prevent late cicatricial complications in eyes with mild and moderate acute alkaline burns.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Apósitos Biológicos
/
Quemaduras Químicas
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Quemaduras Oculares
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Enfermedades de la Conjuntiva
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Enfermedades de la Córnea
Tipo de estudio:
Observational_studies
Límite:
Adult
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arch Ophthalmol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos