Propolis suppresses tumor angiogenesis by inducing apoptosis in tube-forming endothelial cells.
Biosci Biotechnol Biochem
; 72(9): 2436-40, 2008 Sep.
Article
en En
| MEDLINE
| ID: mdl-18776674
ABSTRACT
We have reported that propolis suppresses tumor-induced angiogenesis in vivo and in vitro, but antiangiogenic mechanism of propolis at cellular level remains unclear. In this study, we observed that propolis not only inhibited tube formation but also induced apoptosis of endothelial cells. These results suggest that propolis exerts its antiangiogenic effects at least in part through induction of apoptosis.
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Base de datos:
MEDLINE
Asunto principal:
Própolis
/
Apoptosis
/
Inhibidores de la Angiogénesis
/
Células Endoteliales
/
Neovascularización Patológica
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón