The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains.
J Neuroimmunol
; 204(1-2): 43-51, 2008 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-18817984
ABSTRACT
The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-gamma, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
1-Metil-4-fenil-1,2,3,6-Tetrahidropiridina
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Astrocitos
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Citocinas
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Microglía
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Neurotoxinas
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón