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The jury is in: p73 is a tumor suppressor after all.
Rosenbluth, Jennifer M; Pietenpol, Jennifer A.
Afiliación
  • Rosenbluth JM; Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennesee 37232, USA.
Genes Dev ; 22(19): 2591-5, 2008 Oct 01.
Article en En | MEDLINE | ID: mdl-18832062
While p53 has been extensively characterized as a tumor suppressor, it has been more difficult to determine whether p63 and/or p73 play a similar role. Every system in which these family members have been studied, from cells to animal models to human tissues, seems to create more questions than answers. Tomasini and colleagues (2677-2691) demonstrate that one isoform of p73 is responsible for preventing tumor formation in vivo, providing critical validation of an isoform-based model of p73 function.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Genes Supresores de Tumor / Proteínas Supresoras de Tumor / Proteínas de Unión al ADN Tipo de estudio: Etiology_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Genes Dev Asunto de la revista: BIOLOGIA MOLECULAR Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Genes Supresores de Tumor / Proteínas Supresoras de Tumor / Proteínas de Unión al ADN Tipo de estudio: Etiology_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Genes Dev Asunto de la revista: BIOLOGIA MOLECULAR Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos