Randomised, double-blind, placebo-controlled clinical trial of a new topical glyceryl trinitrate patch for chronic lateral epicondylosis.
Br J Sports Med
; 43(4): 299-302, 2009 Apr.
Article
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| MEDLINE
| ID: mdl-18971247
ABSTRACT
OBJECTIVE:
This study aimed to determine whether a new glyceryl trinitrate patch preparation is effective in treating chronic lateral epicondylosis.DESIGN:
Randomised double-blind controlled clinical trial.SETTING:
Private practice PATIENTS 154 adult patients with chronic lateral epicondylosis were recruited, with 136 patients completing the trial.INTERVENTIONS:
8 weeks of glyceryl trinitrate patch application (dosages of 72 mg/24 h, 1.44 mg/24 h, and 3.6 mg/24 h), or placebo patch application. MAIN OUTCOMEMEASURES:
Subjective global assessment of change in elbow symptoms, patient-rated tennis elbow evaluation, visual analogue pain at rest, visual analogue pain with activity, visual analogue pain intensity, grip strength, and strength testing using the Orthopaedic Research Institute-Tennis Elbow Testing System.RESULTS:
At 8 weeks there was a significant decrease in elbow pain with activity in the glyceryl trinitrate 0.72 mg/24 h group compared with placebo (p = 0.04). There were no other significant differences.CONCLUSIONS:
Continuous 1.25 mg/24 h topical glyceryl trinitrate treatment, when combined with daily exercise rehabilitation, has previously demonstrated efficacy in treating chronic lateral epicondylosis. There was significantly decreased elbow pain with activity at 8 weeks in the glyceryl trinitrate 0.72 mg/24 h group (p = 0.04). This short-term dose-ranging study did not demonstrate a treatment effect of a new topical glyceryl trinitrate patch in dosages of 1.44 mg/24 h or 3.6 mg/24 h, which conflicts with previous studies on topical glyceryl trinitrate treatment. TRIAL REGISTRATION NUMBER NCT00447928.
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Codo de Tenista
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Nitroglicerina
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Analgésicos
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
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Adult
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Aged
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Humans
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Middle aged
Idioma:
En
Revista:
Br J Sports Med
Año:
2009
Tipo del documento:
Article