Low cost combination of DCIP and MCV was better than that of DCIP and OF in the screening for hemoglobin E.
J Med Assoc Thai
; 91(10): 1499-504, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18972891
ABSTRACT
OBJECTIVE:
To evaluate hemoglobin E screening tests in a large scale of cases. MATERIAL ANDMETHOD:
A cross-sectional descriptive study was conducted Whole blood obtained from subjects was evaluated for CBC, OF, DCIP, and hemoglobin typing.RESULTS:
Five hundred twenty seven hemoglobin E and 280 reference subjects participated. DCIP's sensitivity, specificity, positive predictive value, and negative predictive value were 97.16%, 98.93%, 99.42%, and 95.19%, respectively. These values of OF were 69.12%, 80.00%, 86.67%, and 57.88%, respectively. In the combination of DCIP and OF gave rise to these values of 99.43%, 79.29%, 90.03%, and 96.67%, respectively. Finally the combination of DCIP and MCV < 80 fL resulted in these values to be 99.43%, 98.93%, 99.43%, and 98.93%, respectively. False positive and false negative rate were 1.07% and 0.57%, respectively.CONCLUSION:
Combination of DCIP and MCVwas better than that of DCIP and OF in hemoglobin E screening.
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Base de datos:
MEDLINE
Asunto principal:
Talasemia
/
Hemoglobina E
/
Tamizaje Masivo
/
2,6-Dicloroindofenol
/
Índices de Eritrocitos
Tipo de estudio:
Diagnostic_studies
/
Health_economic_evaluation
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Med Assoc Thai
Año:
2008
Tipo del documento:
Article
País de afiliación:
Tailandia