The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age.
Heart
; 95(10): 825-9, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-19147626
ABSTRACT
BACKGROUND:
It is unclear whether age-related increases in N-terminal pro-brain natriuretic peptide (NT-proBNP) represent a normal physiological process-possibly affecting the prognostic power-of NT-proBNP-or reflect age-related subclinical pathological changes.OBJECTIVE:
To determine the effect of age on the short-term prognostic value of NT-proBNP in patients with chronic heart failure (CHF).DESIGN:
Prospective observational study with inclusion and matching of consecutive patients aged >65 years (mean (SD) 73.1 (6.0) years) to patients <65 years (53.7 (8.6) years) with respect to NT-proBNP, New York Heart Association stage, sex and aetiology of CHF (final n = 443).SETTING:
University hospital outpatient departments in the UK and Germany. PATIENTS Chronic stable heart failure due to systolic left ventricular dysfunction. INTERVENTION None. OUTCOMEMEASURE:
All-cause mortality.RESULTS:
In both age groups, NT-proBNP was a significant univariate predictor of mortality, and independent of age, sex and other established risk markers. The prognostic information given by NT-proBNP was comparable between the two groups, as reflected by the 1-year mortality of 9% in both groups. The prognostic accuracy of NT-proBNP as judged by the area under the receiver operating characteristics curve for the prediction of 1-year mortality was comparable for elderly and younger patients (0.67 vs 0.71; p = 0.09).CONCLUSION:
NT-proBNP reflects disease severity in elderly and younger patients alike. In patients with chronic stable heart failure, the NT-proBNP value carries the same 1-year prognostic information regardless of the age of the patient.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
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Disfunción Ventricular Izquierda
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Péptido Natriurético Encefálico
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Insuficiencia Cardíaca
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Heart
Asunto de la revista:
CARDIOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Alemania