Urinary tract infections and reduced risk of bladder cancer in Los Angeles.
Br J Cancer
; 100(5): 834-9, 2009 Mar 10.
Article
en En
| MEDLINE
| ID: mdl-19174821
ABSTRACT
We investigated the association between urinary tract infections (UTIs) and transitional cell carcinoma of the bladder in a population-based case-control study in Los Angeles covering 1586 cases and age-, gender-, and race-matched neighbourhood controls. A history of bladder infection was associated with a reduced risk of bladder cancer among women (odds ratio (OR), 0.66; 95% confidence interval (CI), 0.46-0.96). No effect was found in men, perhaps due to power limitations. A greater reduction in bladder cancer risk was observed among women with multiple infections (OR, 0.37; 95% CI, 0.18-0.78). Exclusion of subjects with a history of diabetes, kidney or bladder stones did not change the inverse association. A history of kidney infections was not associated with bladder cancer risk, but there was a weak association between a history of other UTIs and slightly increased risk among men. Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Infecciones Urinarias
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Neoplasias de la Vejiga Urinaria
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Carcinoma de Células Transicionales
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Br J Cancer
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos