[Clinical application of prefilled pen and conventional syringe during controlled ovarian stimulation for in vitro fertilization].
Nan Fang Yi Ke Da Xue Xue Bao
; 29(1): 100-4, 2009 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-19218125
ABSTRACT
OBJECTIVE:
To investigate the efficacy, convenience and costs of recombinant follitropin alpha administered by a prefilled pen device and conventional syringe in Chinese women undergoing controlled ovarian stimulation for in vitro fertilization (IVF).METHODS:
A total of 184 patients undergoing IVF treatment were enrolled in this study. According to a long-term recombinant follicle-stimulating hormone (rFSH) protocol, ovarian stimulation was performed with the prefilled pen and conventional syringe at random in these subjects, and the dose of follitropin, number of oocytes and embryo parameters and IVF-ET outcome were compared between the two groups.RESULTS:
The total rFSH dose, cost, and frequency of hospital visits were significantly lower in the pen protocol group, but the residual rFSH amount was higher. Compared with conventional injections, the prefilled pen was associated with significantly lowered rate of local redness, high rate of local bruise, more frequent follitropin dose modulation and lower serum oestradiol levels on HCG day. No significant difference was found in the endometrial thickness, numbers of oocytes retrieved, MII oocytes, transferred embryo, or the clinical pregnancy rates between the two groups. The ratio of MII oocytes, good quality embryo rates and implantation rates was significantly higher in the pen group with lower incidences of moderate and severe ovarian hyperstimulation syndrome.CONCLUSION:
The prefilled pen provides an easy, safe, effective and more patient-friendly means for controlled ovarian stimulation procedure in Chinese women, but more attention should be given to protocol optimization and patient education.
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Base de datos:
MEDLINE
Asunto principal:
Inducción de la Ovulación
/
Proteínas Recombinantes
/
Fertilización In Vitro
/
Hormona Folículo Estimulante
Tipo de estudio:
Clinical_trials
/
Guideline
Límite:
Adult
/
Female
/
Humans
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Año:
2009
Tipo del documento:
Article
País de afiliación:
China