Amygdala protein kinase C epsilon controls alcohol consumption.
Genes Brain Behav
; 8(5): 493-9, 2009 Jul.
Article
en En
| MEDLINE
| ID: mdl-19243450
ABSTRACT
Alcoholism is a progressive disorder that involves the amygdala. Mice lacking protein kinase C epsilon (PKCepsilon) show reduced ethanol consumption, sensitivity and reward. We therefore investigated whether PKCepsilon signaling in the amygdala is involved in ethanol consumption. Local knockdown of PKCepsilon in the amygdala reduced ethanol consumption and preference in a limited-access paradigm. Further, mice that are heterozygous for the PKCepsilon allele consume less ethanol compared with wild-type mice in this paradigm. These mice have a >50% reduction in the abundance of PKCepsilon in the amygdala compared with wild-type mice. We conclude that amygdala PKCepsilon is important for ethanol consumption in mice.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Trastornos del Sistema Nervioso Inducidos por Alcohol
/
Alcoholismo
/
Proteína Quinasa C-epsilon
/
Amígdala del Cerebelo
Límite:
Animals
Idioma:
En
Revista:
Genes Brain Behav
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
GENETICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos