IRS-2 and its involvement in diabetes and aging.
Vitam Horm
; 80: 389-407, 2009.
Article
en En
| MEDLINE
| ID: mdl-19251045
ABSTRACT
Insulin receptor substrate 2 (IRS-2) is a key molecule in insulin signaling pathway, serving as an adaptor protein to insulin receptor to activate downstream kinase cascades, including MAP kinase and PI-3 kinase cascades. While reduced IRS-2 expression is tightly associated with diabetes and insulin resistance in various rodent diabetic models, this gene is also suggested to play a critical role in reproductive system and pancreas development. Recently, IRS-2 is demonstrated to be actively involved in lifespan regulation. In this chapter, we attempt to give a brief review of what we have learned about this molecule in metabolism and growth.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Diabetes Mellitus
/
Proteínas Sustrato del Receptor de Insulina
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Vitam Horm
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos