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Does treatment with proton pump inhibitors for gastroesophageal reflux disease (GERD) improve asthma symptoms in children with asthma and GERD? A systematic review.
Sopo, S Miceli; Radzik, D; Calvani, M.
Afiliación
  • Sopo SM; Department of Pediatrics, Catholic University of Rome, Rome, Italy smicelisopo@rm.unicatt.it
Article en En | MEDLINE | ID: mdl-19274922
ABSTRACT

OBJECTIVE:

To evaluate pediatric studies of the effect on asthma symptoms of treatment with proton pump inhibitors (PPI) used to treat gastroesophageal reflux disease (GERD).

METHODS:

We entered the MeSH terms "gastroesophageal reflux AND asthma AND children" in the PubMed tool Clinical Queries, selecting "therapy" and "broad, sensitive search." The search ended on April 14, 2008. We included only clinical trials performed in pediatric patients.

RESULTS:

Four studies were considered to be relevant, although only 1 was a randomized, double-blind, placebo-controlled trial. The 3 nonrandomized trials showed that PPIs benefited patients with asthma. The randomized, double-blind, placebo-controlled trial found that omeprazole did not improve asthma symptoms. An improved (although not statistically significant) score was observed in the quality of life questionnaire in children with a reflux index greater than 10% and in those with more severe asthma treated with omeprazole compared with the placebo group.

CONCLUSIONS:

Scant data in these studies mean that we cannot make solid recommendations. However, in specific cases, we think that treatment of asthma symptoms with a PPI is valid as long as at least 2 conditions are satisfied asthma must not respond to standard treatment, and 1 instrumental parameter of GERD severity must be satisfied, that is, a reflux index greater than or equal to 10 must be present.
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Base de datos: MEDLINE Asunto principal: Asma / Omeprazol / Reflujo Gastroesofágico / Inhibidores de la Bomba de Protones Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Systematic_reviews Límite: Child / Humans Idioma: En Revista: J Investig Allergol Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Italia
Buscar en Google
Base de datos: MEDLINE Asunto principal: Asma / Omeprazol / Reflujo Gastroesofágico / Inhibidores de la Bomba de Protones Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Systematic_reviews Límite: Child / Humans Idioma: En Revista: J Investig Allergol Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Italia