Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists.
Bioorg Med Chem Lett
; 19(10): 2637-41, 2009 May 15.
Article
en En
| MEDLINE
| ID: mdl-19376703
ABSTRACT
Two classes of amino acid-derived heterocyclic progesterone receptor ligands were developed to address the metabolic issues posed by the dimethyl amide functionality of the lead compound (1). The tetrazole-derived ligands behaved as potent partial agonists, while the 1,2,4-triazole ligands behaved as potent full agonists.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Tetrazoles
/
Receptores de Progesterona
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos