The importance of apoptosis for immune regulation in Chagas disease.
Mem Inst Oswaldo Cruz
; 104 Suppl 1: 259-62, 2009 Jul.
Article
en En
| MEDLINE
| ID: mdl-19753482
ABSTRACT
Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates the growth of T. cruzi inside host macrophages. In spite of progress made in this area, the importance of apoptosis in the pathogenesis of Chagas disease remains unclear. Here we review the evidence of apoptosis in mice and humans infected with T. cruzi. We also discuss the mechanisms by which apoptosis can influence underlying host responses and tissue damage during Chagas disease progression.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trypanosoma cruzi
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Enfermedad de Chagas
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Apoptosis
/
Interacciones Huésped-Parásitos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Año:
2009
Tipo del documento:
Article
País de afiliación:
Brasil