Synthesis and study of some new 1,3-isoindoledione derivatives as potential antibacterial agents.
Eur J Med Chem
; 45(4): 1552-9, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20117862
ABSTRACT
In an effort to establish new candidates with improved antibacterial activities, we reported here the synthesis and in vitro antibacterial evaluation of various series of 2-substituted-3a,4,9,9a-tetrahydro-4,9-benzeno-benz[f]isoindole-1,3-diones 4-acetyl-phenyl 2, 2,2-dibromoacetylphenyl 3, benzimidazole 4, acetylbenzimidazole 5, aminophenyl 6, acetamide 7, naphthalene 8, disulfide 9, mercaptophenyl 10, hydroxyphenyl 11, phenyl ester 12, triazole 13, benzothiophene 14, benzothiazole 15 phenylazo 16a, b and aminomethane 17 derivatives. The newly synthesized compounds were characterized by (IR, (1)H NMR, (13)C NMR and mass spectrum studies). Representative compounds of the synthesized products were established and evaluated as antibacterial agents.
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1
Base de datos:
MEDLINE
Asunto principal:
Indoles
/
Antibacterianos
Idioma:
En
Revista:
Eur J Med Chem
Año:
2010
Tipo del documento:
Article
País de afiliación:
Egipto