Sialoblastoma of salivary glands in children: chemotherapy should be discussed as an alternative to mutilating surgery.
Int J Pediatr Otorhinolaryngol
; 74(8): 942-5, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20554035
ABSTRACT
Sialoblastoma is a very rare congenital salivary gland tumor. No consensus has been reached concerning the treatment of this tumor due to its rarity. The treatment of reference is surgery, which can be mutilating, in the case of a locally invasive tumor. The treatment of metastatic disease is also controversial. The authors report a new case of a 6-year-old girl with a progressively growing left parotid mass since birth. The first cytological diagnosis was that of pleomorphic adenoma. Due to local progression, superficial parotidectomy was performed at the age of 3.5 years and revealed a diagnosis of sialoblastoma. Six months later, local recurrence and lung metastasis were treated by neoadjuvant chemotherapy with a very good partial response on the local recurrence and the lung metastasis, allowing complete parotidectomy with sacrifice of the facial nerve. Bilateral lung biopsies after adjuvant chemotherapy showed total necrosis. No recurrence was observed with a follow-up of 1 year. This case and a review of the literature confirm the very good chemosensitivity of this tumor and argue in favor of neoadjuvant chemotherapy for locally invasive tumors rather than extensive mutilating surgery.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de las Glándulas Salivales
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Protocolos de Quimioterapia Combinada Antineoplásica
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Adenoma Pleomórfico
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Neoplasias Pulmonares
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Recurrencia Local de Neoplasia
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Child
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Female
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Humans
Idioma:
En
Revista:
Int J Pediatr Otorhinolaryngol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia