[Effects of medicinal extract for tonifying kidney to relieve asthma on glucocorticoid receptor expression in lung tissues of rats with bronchial asthma].
Zhong Xi Yi Jie He Xue Bao
; 8(8): 785-9, 2010 Aug.
Article
en Zh
| MEDLINE
| ID: mdl-20727335
ABSTRACT
OBJECTIVE:
To observe the effects of medicinal extract for tonifying kidney to relieve asthma on glucocorticoid receptor (GR) expression in rats with asthma, and to explore its mechanism in treating asthma.METHODS:
Sixty SD rats were randomly divided into normal control group, untreated group, dexamethasone group, and medicinal extract-prevented, medicinal extract-treated, and medicinal extract-prevented and -treated groups, with ten rats in each group. Asthma was induced by intraperitoneal injection of ovalbumin (OVA) and forced inhalation of atomized OVA. Expression of GR in lung tissues was detected by immunohistochemical method. Pathological changes of the lung tissues were observed by HE straining.RESULTS:
Expression of GR was lower in the untreated group than in the normal control group (P<0.05). Expressions of GR in medicinal extract groups were up-regulated as compared with those in the untreated group and dexamethasone group (P<0.05, P<0.01), and there were no significant differences as compared with the normal control group (P>0.05).CONCLUSION:
Medicinal extract for tonifying kidney to relieve asthma can increase the expression of GR in lung tissues of asthmatic rats, which may be one of its mechanisms in preventing and treating asthma.
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Base de datos:
MEDLINE
Asunto principal:
Asma
/
Medicamentos Herbarios Chinos
/
Receptores de Glucocorticoides
/
Riñón
/
Pulmón
Límite:
Animals
Idioma:
Zh
Revista:
Zhong Xi Yi Jie He Xue Bao
Asunto de la revista:
MEDICINA
/
TERAPIAS COMPLEMENTARES
Año:
2010
Tipo del documento:
Article
País de afiliación:
China