Glucose balance of porcine liver allograft is an important predictor of outcome.
J Surg Res
; 171(2): 851-8, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-20828723
ABSTRACT
BACKGROUND:
The role of glucose metabolism in predicting postoperative liver graft function after transplantation is unclear. We investigated the relation between intraoperative glucose balance of the liver allograft and the postoperative graft function and survival in a porcine partial liver transplant model. MATERIALS ANDMETHODS:
Experiments follow Guiding Principles in the Care and Use of Animals. Fourteen female pigs received liver allografts of 17%-39% recipient liver volume. Recipients were classified into two groups based on positive glucose balance the mean intraoperative blood glucose of the graft outflow was greater than the blood glucose of inflow, negative glucose balance the mean blood glucose of graft outflow was less than blood glucose of inflow. Perioperative data and survival were studied.RESULTS:
In the positive group (n=9) intraoperative hepatic artery flow was significantly higher (P=0.028), and oxygen consumption was lower (P=0.018) than the negative group (n=5). Postoperatively, maximal serum aspartate aminotransferase (AST) (P=0.028), alanine aminotransferase (ALT) (P=0.028), and total bilirubin (P=0.027) of the positive group were significantly lower than the negative group. In survival analysis, the positive group had significantly better survival rate than the negative group (P=0.034). Using Periodic acid-Schiff staining, glycogen content of the allograft in the positive group at 10 min post-reperfusion was significantly decreased in comparison with the baseline value in the normal liver (P=0.005), however not statistically different in the negative group (P=0.175).CONCLUSION:
Intraoperative glucose balance can be used as an early predictor of the graft function following transplantation of partial liver allografts.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
/
Glucemia
/
Trasplante de Hígado
/
Supervivencia de Injerto
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Surg Res
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos