Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin's lymphoma treated with radiotherapy.
Br J Cancer
; 103(7): 1081-4, 2010 Sep 28.
Article
en En
| MEDLINE
| ID: mdl-20842115
ABSTRACT
BACKGROUND:
It is unknown whether breast cancer (BC) characteristics among young women treated with radiotherapy (RT) for Hodgkin's lymphoma (HL) differ from sporadic BC.METHODS:
Using population-based data, we calculated BC risk following HL according to clinicopathologic features.RESULTS:
Compared with BC in the general population, risks of oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative BC in young, irradiated HL survivors were increased five-fold (95% confidence interval (CI)=3.81-6.35) and nine-fold (95% CI=6.93-12.25), respectively. Among 15-year survivors, relative risk of ER-negative/PR-negative BC exceeded by two-fold (P=0.002) than that of ER-positive/PR-positive BC.CONCLUSION:
Radiotherapy may disproportionately contribute to the development of BC with adverse prognostic features among young HL survivors.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
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Enfermedad de Hodgkin
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Neoplasias Primarias Secundarias
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Neoplasias Inducidas por Radiación
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Br J Cancer
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos