Poorly treated or unrecognized GERD reduces quality of life in patients with COPD.
Dig Dis Sci
; 56(7): 1976-80, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21221789
ABSTRACT
BACKGROUND:
The effect of gastroesophageal reflux disease (GERD) on health-related quality of life (HRQL) in COPD has never been assessed.AIM:
To evaluate HRQL in patients with COPD alone compared with those with both COPD and continuing GERD symptoms.METHODS:
A questionnaire-based, cross-sectional survey was performed. Subjects were recruited from the outpatient pulmonary clinics at the University of Florida Health Science Center/Jacksonville. Included patients had an established diagnosis of COPD. Exclusion criteria were respiratory disorders other than COPD, known esophageal disease, active peptic ulcer disease, Zollinger-Ellison syndrome, mastocytosis, scleroderma, and current alcohol abuse. Those meeting the criteria and agreeing to participate were asked to complete the Mayo Clinic GERQ and SF-36 questionnaires, by either personal or telephone interview. Clinically significant reflux was defined as heartburn and/or acid regurgitation weekly. Study patients were divided into two groups for HRQL analysis based on the GERQ response COPD+/GERD+ and COPD only. Statistical analysis was performed using the Mann-Whitney-Wilcoxon T test for unequal variables and linear regression was performed using ANOVA. All data are expressed as mean and standard deviation.RESULTS:
Eighty-six patients completed both questionnaires. Males were 55% and COPD+/GERD+ patients comprised 37% of the study group. Compared with COPD only, HRQL was reduced across all measures for the COPD+ GERD+ patients and achieved significance for bodily pain (P < 0.02), mental health (P < 0.05), and physical component score (P < 0.05).CONCLUSION:
Patients with COPD and continuing GERD symptoms have reduced HRQL in comparison with those with COPD alone.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Calidad de Vida
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Reflujo Gastroesofágico
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Enfermedad Pulmonar Obstructiva Crónica
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Dig Dis Sci
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos