Clinical evolution of patients with respiratory allergic disease due to sensitisation to Alternaria alternata being treated with subcutaneous immunotherapy.
Allergol Immunopathol (Madr)
; 39(2): 79-84, 2011.
Article
en En
| MEDLINE
| ID: mdl-21236554
ABSTRACT
INTRODUCTION:
Sensitisation to Alternaria is a cause of respiratory disease in Spain, particularly in childhood, but it is also a significant marker of the severity of this disease. Therefore, the use of an aetiological treatment (allergen specific immunotherapy) is essential, and both subjective and objective clinical parameters should be used to follow up this treatment.OBJECTIVE:
This open-label, uncontrolled, observational, prospective study was designed in order to study the evolution of these patients on allergen specific immunotherapy therapy in daily clinical practice and to assess the use of different monitoring tools. MATERIAL ANDMETHODS:
A total of 99 patients were included. They were monosensitised to this perennial allergen and treated with subcutaneous allergen specific immunotherapy. After one year of follow-up, these patients were assessed for the presence of symptoms, use of medication, clinical incidents, quality of life and asthma control.RESULTS:
After one year of treatment a significant fall was observed in the use of concomitant medication (ß2-agonists p=0.0278, inhaled corticosteroids p=0.0007, anti-leukotrienes p=0.0495), nasal symptoms (p=0.0081), quality of life (PAQLQ, p<0.0001) and asthma control (ACQ, p<0.0001). Twenty-one patients had to attend emergency department due to exacerbation of their allergic disease, and only one of them had to be admitted to hospital.CONCLUSION:
respiratory allergic disease due to Alternaria alternata is a disease which is hard to control, and in our daily practice, the use of specific subcutaneous immunotherapy can be of significant benefit in our paediatric patients.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Hipersensibilidad Respiratoria
/
Desensibilización Inmunológica
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Allergol Immunopathol (Madr)
Año:
2011
Tipo del documento:
Article
País de afiliación:
España