[Synthesis of thienopyridine derivatives and its anti-platelet activity in vivo].
Yao Xue Xue Bao
; 46(1): 70-4, 2011 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-21465811
ABSTRACT
To explore novel ADP receptor inhibitors with anti-thrombotic activity, eighteen compounds were synthesized and their structures were confirmed by 1H NMR and MS. The results showed that the activity of compound C1 was superior to ticlopidine in platelet aggregation inhibition tests in vivo and worthy for further investigation. Compounds A4, B2, C4 and C7 possessed moderate platelet aggregation inhibitory activities.
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Base de datos:
MEDLINE
Asunto principal:
Inhibidores de Agregación Plaquetaria
/
Agregación Plaquetaria
/
Tienopiridinas
Límite:
Animals
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2011
Tipo del documento:
Article
País de afiliación:
China