[Expression and clinical significance of VEGF in tissue of primary hepatocellular carcinoma].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 27(2): 199-202, 2011 Feb.
Article
en En
| MEDLINE
| ID: mdl-21560439
ABSTRACT
AIM:
To study the expression and clinical significance of vaseular endothelial growth factor (VEGF) in tissue of primary hepatocellular carcinoma (PHC) and effects on tumor invasion and metastasis.METHODS:
The VEGF expression from 60 cases of PHC tissues, 30 cases of adjacent tissues and 30 cases of normal tissue were detected by SP immunohistochemical method.RESULTS:
The VEGF positive rate of the PHC group was 68.3%, the adjacent tissues group was 40.0%, and the normal tissue group was 33.3%, compared the different was significant (P<0.05); The VEGF positive rate of the incomplete capsule tissues was 92.9%, which was significantly higher than the complete capsule tissues (P<0.05); and the VEGF positive rate was no significantly different among the different TNM stage, different degree of tumor differentiation and different lesion size (P<0.05).CONCLUSION:
The VEGF has high expression in PHC tissues. The VEGF expression has close relation with the whether tumor capsule and distant metastasis. The VEGF plays an important role angiogenesis of PHC, growth and metastasis.
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Base de datos:
MEDLINE
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Carcinoma Hepatocelular
/
Factores de Crecimiento Endotelial Vascular
/
Neoplasias Hepáticas
Límite:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
China