Adjunctive gabapentin for treatment-resistant insomnia of bipolar disorder: a case report.
Clin Neuropharmacol
; 34(3): 129-30, 2011.
Article
en En
| MEDLINE
| ID: mdl-21586919
ABSTRACT
We report a case with bipolar II disorder having mixed features, in which refractory insomnia persisted. We diagnosed his case as mixed depression with mood fluctuations because increased impulsivity and buying sprees became remarkable, with diminished ability to think or concentrate. Switching to carbamazepine and risperidone improved his mood fluctuations and impulsivity. Nevertheless, his intermittent awakening (fragmentation of the sleep-wake rhythm), related dysfunctional beliefs, anxiety about sleep, and mild impulsivity persisted. The addition of various benzodiazepine sleeping drugs, bromovalerylurea, and antipsychotics did not improve insomnia. His intractable insomnia was markedly responsive to gabapentin, engendering further improvement of mood symptoms. Eventually, its efficacy achieved his reinstatement at work. Results of this case suggest the clinical use of gabapentin for treating bipolar disorder, especially in cases with intractable insomnia, which is a very important point in the symptoms and therapeutics of bipolar disorder.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trastorno Bipolar
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Ácidos Ciclohexanocarboxílicos
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Ácido gamma-Aminobutírico
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Aminas
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Trastornos del Inicio y del Mantenimiento del Sueño
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Clin Neuropharmacol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón