[Use of sunitinib in metastatic renal cell carcinoma patients with poor prognosis].
Vopr Onkol
; 57(1): 50-4, 2011.
Article
en Ru
| MEDLINE
| ID: mdl-21598708
ABSTRACT
We evaluated overall and relapse-free survival in patients with metastatic renal cell carcinoma (MRCC) with poor prognosis. The study involved 92 patients (median age 54.1 years, male 63%, female 29%), retrospectively; 48.9% had poor prognosis. They received oral sunitinib 59 mg/day in 6 cycles (4 weeks on, 2 weeks off). Median overall survival was 17.6 months, relapse-free--10.8 months. Risk of progression in the poor and good prognosis groups was identical (HR=09). Overall response was 29% in poor prognosis and 40%--in good one (p = 0.07). Drug tolerability was acceptable in both groups. Sunitinib was effective in both groups of MRCC patients.
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Base de datos:
MEDLINE
Asunto principal:
Pirroles
/
Carcinoma de Células Renales
/
Indoles
/
Neoplasias Renales
/
Antineoplásicos
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Vopr Onkol
Año:
2011
Tipo del documento:
Article