Improved performance by replacing iminodiacetic residues with glyceryl residues in symmetrically branched oligoglycerols.
Bioorg Med Chem Lett
; 21(16): 4724-7, 2011 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-21757340
ABSTRACT
Synthesis of a symmetrically branched diglycerol (BGL002, involving one iminodiacetic residue) as a G2 dendron, and the tetradecaglycerol (BGL014, involving one iminodiacetic residue) as a G4 dendron, is described. Several members of the BGL family of G2-G4 dendrons were assembled, with G2 bearing four hydroxyl groups at the terminus region, G3 bearing eight, and G4 bearing sixteen. It is noteworthy that triglycerol (BGL003, including no iminodiacetic residue), has a water-solubility ten times higher than BGL002, and the liposome surrounded by BGL014 has a duration period in blood vessel roughly two times longer than the liposome surrounded by dodecaglycerol (BGL012, including three iminodiacetic residues).
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Glicerol
/
Iminoácidos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón