Development of a potassium ion-selective fluorescent sensor based on 3-styrylated BODIPY.
Bioorg Med Chem Lett
; 21(20): 6090-3, 2011 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-21906942
ABSTRACT
We have developed a red-emitting fluorescent K(+) probe, B3TAC, which also shows a wavelength shift upon binding to K(+). The probe was synthesized by conjugating a cryptand-based chelator, 2-triazacryptand [2,2,3]-1-(2-methoxyethoxy)benzene (TAC), to position 3 of the BODIPY fluorophore through a styryl linker. In water-acetonitrile mixed solvent, it responded to K(+) in the physiological concentration range with high selectivity over Na(+) and other metal ions. B3TAC is potentially useful for measuring cellular K(+) ion concentration, as well as for simple, naked-eye detection of K(+) in solution.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Potasio
/
Compuestos de Boro
/
Colorantes Fluorescentes
/
Iones
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón