Long-term experience with everolimus in kidney transplantation in the United States.
Transplant Proc
; 43(7): 2562-7, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-21911123
ABSTRACT
BACKGROUND:
Limited long-term data exist on US kidney transplant patients who have received everolimus at time of transplantation.METHODS:
Using data from the United Network for Organ Sharing/Organ Procurement Transplant Network database, we described patient characteristics and outcomes among adult patients who received a kidney transplant between 1998 and 2007 and received everolimus maintenance immunosuppression (n = 392) at time of discharge. Outcomes included acute rejection, new-onset diabetes posttransplant, primary graft failure, and serum creatinine. We included single-organ, first-time transplants between 1998 and 2007 as a reference group.RESULTS:
Primary graft survival at 3 and 5 years posttransplantation was 87.2% ± 2.1% (95% confidence interval [CI] 82.5%-90.7%) and 77.4% ± 3.0% (95% CI 70.8%-82.7%), respectively, in the everolimus-treated group. Improved graft survival with everolimus seemed to be more pronounced in recipients of deceased donor transplants despite the fact that everolimus-treated patients quantitatively had a higher rate of acute rejection at 3 years posttransplant versus the reference group.CONCLUSION:
Although the incidence of acute rejection was slightly higher in the everolimus-treated patients, graft survival at 3 and 5 years posttransplantation favored everolimus, with the effect being particularly notable in the recipients who received deceased donor renal transplants.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
/
Sirolimus
/
Inmunosupresores
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Transplant Proc
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos