Co-trimoxazole effect on human alveolar macrophages of AIDS patients.
J Biol Regul Homeost Agents
; 25(3): 461-4, 2011.
Article
en En
| MEDLINE
| ID: mdl-22023771
ABSTRACT
Compelling evidence suggests that co-trimoxazole prophylaxis reduces mortality in HIV-infected patients, although it is unclear whether these effects are directly related to antimicrobial activities. We evaluated in vitro phagocytosis and killing of Staphylococcus aureus in alveolar macrophages (AM) obtained from AIDS patients who smoke, treated (n=19) or not treated (n=13) with co-trimoxazole, as compared to non-HIV-infected healthy smokers (n=15). Phagocytosis and killing of Staphylococcus aureus by AM obtained from non-co-trimoxazole treated AIDS patients were significantly lower compared to non-HIV-infected healthy smokers. In contrast, AIDS patients treated with co-trimoxazole prophylaxis showed phagocytosis and killing levels similar to those of healthy controls. These results might help to clarify the observed positive effect of co-trimoxazole on survival in HIV-infected patients.
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Base de datos:
MEDLINE
Asunto principal:
Fagocitosis
/
Staphylococcus aureus
/
Combinación Trimetoprim y Sulfametoxazol
/
Síndrome de Inmunodeficiencia Adquirida
/
Macrófagos Alveolares
/
Antiinfecciosos
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Biol Regul Homeost Agents
Asunto de la revista:
BIOLOGIA
/
BIOQUIMICA
Año:
2011
Tipo del documento:
Article