Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction.
Placenta
; 33(1): 77-80, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22115498
ABSTRACT
Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone (1a1) and cholesterol (1a2, 1a6) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Placenta
/
Proteínas Gestacionales
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Fertilización In Vitro
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Glucuronosiltransferasa
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Inyecciones de Esperma Intracitoplasmáticas
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Infertilidad Femenina
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Hígado
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Placenta
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos