Prostate cancer risk in men with baseline history of coronary artery disease: results from the REDUCE Study.
Cancer Epidemiol Biomarkers Prev
; 21(4): 576-81, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-22315364
ABSTRACT
BACKGROUND:
Coronary artery disease (CAD) and prostate cancer (PCa) are not only common diseases, but share many risk factors. To date, only a few studies have explored the relationship between CAD and PCa risk, with conflicting results.METHODS:
The four-year REDUCE study tested dutasteride 0.5 mg daily for PCa risk reduction in men with prostate specific antigen (PSA) of 2.5 to 10.0 ng/mL and a negative biopsy. Among men who underwent at least one on-study biopsy (n = 6,729; 82.8%), the association between CAD and overall PCa risk and disease grade was examined with logistic and multinomial logistic regression adjusting for clinicopathologic features, respectively.RESULTS:
Overall, 547 men (8.6%) had a history of CAD. Men with CAD were significantly older and had higher body mass index, PSA, and larger prostate volumes and were more likely to have diabetes, hypertension, and hypercholesterolemia and take aspirin and statins. On multivariate analysis, CAD was associated with a 35% increased risk of PCa diagnosis (OR = 1.35, 95% CI 1.08-1.67, P = 0.007), while elevating risk of both low- (OR = 1.34, 95% CI 1.05-1.73, P = 0.02) and high-grade disease (OR = 1.34, 95% CI 0.95-1.88, P = 0.09).CONCLUSIONS:
In a post hoc hypothesis developing secondary analysis of the REDUCE study, CAD was significantly associated with increased PCa diagnosis. IMPACT If confirmed in other studies, this suggests CAD may be a novel PCa risk factor and suggests common shared etiologies. Whether lifestyle changes shown to reduce CAD risk (i.e., weight loss, exercise, cholesterol reduction, etc.) can reduce PCa risk, warrants further study.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Hiperplasia Prostática
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Neoplasias de la Próstata
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Enfermedad de la Arteria Coronaria
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cancer Epidemiol Biomarkers Prev
Asunto de la revista:
BIOQUIMICA
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EPIDEMIOLOGIA
/
NEOPLASIAS
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos