Pregnancy outcome after exposure to the probiotic Lactobacillus in early pregnancy.
J Obstet Gynaecol
; 32(3): 227-9, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-22369393
ABSTRACT
The present study prospectively assessed pregnancy outcome of women taking probiotics during the periconceptional period. A group of 104 women who had taken Lactobacillus in early pregnancy and 200 age- and parity-matched control pregnant women exposed to non-teratogenic agents were also recruited into the study and followed-up prospectively. Median gestational age of women exposed to Lactobacillus was 5.2 (range 1.9-17.6) weeks. Exposure was at a mean dose of 510 mg/day for a median of 4.0 days (range 1-90 days). In the exposed group, pregnancy outcomes included 96 live births and eight spontaneous abortions versus 187 live births and 21 spontaneous abortions in the non-exposed group. There was no statistical difference in adverse pregnancy outcomes, including the number of spontaneous abortions, pre-term births as well as a low birth weight between the two groups (p > 0.05). In the exposed group, there were two (2.1%) major congenital malformations in comparison with five (2.7%) in the comparison group (p = 0.7). In conclusion, no association was identified between ingestion of Lactobacillus in early pregnancy for a limited period of time and adverse pregnancy outcomes. However, rare pregnancy outcomes may have been missed due to the limited sample size included in the study.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Anomalías Congénitas
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Aborto Espontáneo
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Exposición Materna
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Probióticos
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Nacimiento Prematuro
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Nacimiento Vivo
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Lactobacillus
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
J Obstet Gynaecol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Corea del Sur