Nuclear receptors and AMPK: resetting metabolism.
Cold Spring Harb Symp Quant Biol
; 76: 17-22, 2011.
Article
en En
| MEDLINE
| ID: mdl-22411605
ABSTRACT
Obesity, and in particular central adiposity, is a key feature of metabolic syndrome, which includes trends toward increased triglycerides, insulin resistance, high blood pressure, hypercholesterolemia, and heart disease. It has a prevalence of 25% or more and is a dominant component of the health care budgets in Western societies. In addition to genetic causes, high-fat diets and disrupted sleep patterns have major influences on the development of metabolic syndrome. Recent studies have demonstrated active roles for the nuclear receptor superfamily and the energy-sensing kinase adenosine monophosphate (AMP)-activated protein kinase (AMPK) in regulating metabolism and circadian rhythm. In this chapter, we review these findings and attempt to develop a better understanding of the interplay between metabolism and circadian rhythm and their coordinated regulation by nuclear receptors and AMPK. This supraregulatory network may be considered a target for novel therapeutic applications against metabolic syndrome.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Receptores Citoplasmáticos y Nucleares
/
Redes y Vías Metabólicas
/
Proteínas Quinasas Activadas por AMP
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cold Spring Harb Symp Quant Biol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos