IL-33: a Janus cytokine.
Ann Rheum Dis
; 71 Suppl 2: i101-4, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-22460136
ABSTRACT
Interleukin (IL) 33, a member of the IL-1 family, is the ligand of ST2 that is expressed mainly on activated Th2 cells and mast cells. IL-33 can skew a predominantly Th1 cell population to a mainly Th2 cells phenotype in vivo. IL-33 messenger RNA is expressed early during infection of the intestinal-dwelling nematode Trichuris muris in mice. IL-33 treatment enhances resistance to Trichuris infection. IL-33 also effectively attenuates sepsis by mobilising the innate cells, neutrophils, to the site of infection, helping to clear the pathogens. Thus, IL-33 may be evolutionally preserved for the host defence against infections. IL-33 can reduce an ongoing atherosclerosis in ApoE(-/-) mice and attenuate adipocytes mainly by inducing the production of type II cytokines. In contrast, IL-33 can also exacerbate allergy and the inflammation in collagen-induced or serum-induced arthritis. Hence, IL-33 is a double-edged sword, and targeting IL-33 should be approached with caution.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Interleucinas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Ann Rheum Dis
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido