Noninvasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with 99mTc-HMPAO CBF autoradiography in a rat stroke model.
J Cereb Blood Flow Metab
; 32(6): 973-7, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22472604
ABSTRACT
Arterial spin labelling (ASL) is increasingly available for noninvasive cerebral blood flow (CBF) measurement in stroke research. Here, a pseudo-continuous ASL technique (pCASL) was evaluated against (99m)Tc-D, L-hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) autoradiography in a rat stroke model. The (99m)Tc-HMPAO was injected (intravenously, 225 MBq) during pCASL acquisition. The pCASL and (99m)Tc-HMPAO autoradiography CBF measures, relative to the contralateral hemisphere, were in good agreement across the spectrum of flow values in normal and ischemic tissues. The pCASL-derived quantitative regional CBF values (contralateral 157 to 177 mL/100 g per minute; ipsilateral 9 to 104 mL/100 g per minute) were consistent with the literature values. The data show the potential utility of pCASL for CBF assessment in a rat stroke model.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Marcadores de Spin
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Isquemia Encefálica
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Circulación Cerebrovascular
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Angiografía por Resonancia Magnética
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Radiofármacos
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Exametazima de Tecnecio Tc 99m
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Accidente Cerebrovascular
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido