Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens.
J Immunol
; 188(11): 5389-96, 2012 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-22529295
ABSTRACT
The signals required to generate long-lived plasma cells remain unresolved. One widely cited model posits that long-lived plasma cells derive from germinal centers (GCs) in response to T cell-dependent (TD) Ags. Thus, T cell-independent (TI) Ags, which fail to sustain GCs, are considered ineffective at generating long-lived plasma cells. However, we show that long-lived hapten-specific plasma cells are readily induced without formation of GCs. Long-lived plasma cells developed in T cell-deficient mice after a single immunization with haptenated LPS, a widely used TI Ag. Long-lived plasma cells also formed in response to TD Ag when the GC response was experimentally prevented. These observations establish that long-lived plasma cells are induced in both TI and TD responses, and can arise independently of B cell maturation in GCs.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Células Plasmáticas
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Células de la Médula Ósea
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Diferenciación Celular
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Subgrupos de Linfocitos T
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Epítopos de Linfocito T
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos