Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer.
Oral Dis
; 18(8): 734-40, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-22533572
ABSTRACT
OBJECTIVES:
Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression.METHODS:
In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays.RESULTS:
Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2 P < 0.001; MMP-9 P < 0.001; LCN2/MMP-9 P < 0.01). Plasma levels of LCN2, MMP-9, and LCN2/MMP-9 in patients with OSCC were significantly correlated with each other and were associated with more-advanced clinical stages (P < 0.05) and/or a larger tumor size (P < 0.05), but were not associated with positive lymph-node metastasis or distal metastasis.CONCLUSION:
Our results suggest that plasma levels of LCN2 and the LCN2/MMP-9 complex may be useful in non-invasively monitoring OSCC progression, while supporting their potential role as biomarkers of oral cancer disease status.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Boca
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Carcinoma de Células Escamosas
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Proteínas Proto-Oncogénicas
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Metaloproteinasa 9 de la Matriz
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Lipocalinas
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Oral Dis
Asunto de la revista:
ODONTOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Taiwán