Your browser doesn't support javascript.
loading
Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer's disease.
Park, Yong Dae; Park, Jeong Hoon; Hur, Min Goo; Kim, Sang Wook; Min, Jung-Joon; Park, Seung-Hwan; Yoo, Yung Joon; Yoon, Yong-Jin; Yang, Seung Dae.
Afiliación
  • Park YD; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongup 580-185, Republic of Korea.
Bioorg Med Chem Lett ; 22(12): 4106-10, 2012 Jun 15.
Article en En | MEDLINE | ID: mdl-22578456
Amyloid plaques, which are primarily composed of aggregated amyloid-beta (Aß) peptide, are the neuropathological hallmarks of Alzheimer's disease (AD). Fluorescent markers containing 2-styrylpyridazin-3(2H)-ones were developed to detect intracellular aggregated Aß peptides. Nine compounds exhibited a greater than 10-fold increase of in emission spectra before and after mixing with Aß aggregates compared with before mixing. Among these compounds, compound 9n exhibited the highest affinity for Aß aggregates (K(d)=1.84 µM) and selectively stained both aggregated intracellular Aß and Aß plaques in the transgenic AD model mice (APP/PS1). These preliminary results indicate that 2-styrylpyridazin-3(2H)-one derivatives are promising alternative fluorescence imaging agent for the study of AD.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piridazinas / Péptidos beta-Amiloides / Placa Amiloide / Enfermedad de Alzheimer / Colorantes Fluorescentes Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2012 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piridazinas / Péptidos beta-Amiloides / Placa Amiloide / Enfermedad de Alzheimer / Colorantes Fluorescentes Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2012 Tipo del documento: Article