Nutritional chemoprevention of urinary tract tumors (UTT) induced by lithogenic agents: risk for UTT in children exposed to melamine-contaminated milk formulas.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
; 30(2): 174-87, 2012.
Article
en En
| MEDLINE
| ID: mdl-22690714
ABSTRACT
Urinary tract tumors are tenth in frequency, and many environmental carcinogens are excreted by urine. Interplay between chronic inflammatory urolithiasis and urothelial carcinogenesis is not well understood. Experimental evidences show that dietary melamine induce these events even at low concentrations. This is important because thousands of children were exposed to melamine through intentionally contaminated milk formula worldwide. We propose that an increased risk for urinary tumors in adult life may occur and screenings for early urinary signs may be necessary. Therefore, urothelial biology, melamine carcinogenic potential, and related epidemiology are discussed, recommending a preventive dietary polyunsaturated fatty acid-based supplementation, since they modulate such interplay in rodents.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Triazinas
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Contaminación de Alimentos
/
Neoplasias Urológicas
/
Fórmulas Infantiles
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Urolitiasis
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Ácidos Grasos Insaturados
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Animals
/
Female
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Humans
/
Infant
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Male
/
Newborn
Idioma:
En
Revista:
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
Asunto de la revista:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Argentina