NGAL-Siderocalin in kidney disease.
Biochim Biophys Acta
; 1823(9): 1451-8, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22728330
ABSTRACT
Kidney damage induces the expression of a myriad of proteins in the serum and in the urine. The function of these proteins in the sequence of damage and repair is now being studied in genetic models and by novel imaging techniques. One of the most intensely expressed proteins is lipocalin2, also called NGAL or Siderocalin. While this protein has been best studied by clinical scientists, only a few labs study its underlying metabolism and function in tissue damage. Structure-function studies, imaging studies and clinical studies have revealed that NGAL-Siderocalin is an endogenous antimicrobial with iron scavenging activity. This review discusses the "iron problem" of kidney damage, the tight linkage between kidney damage and NGAL-Siderocalin expression and the potential roles that NGAL-Siderocalin may serve in the defense of the urogenital system. This article is part of a Special Issue entitled Cell Biology of Metals.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Proteínas de Fase Aguda
/
Proteínas Proto-Oncogénicas
/
Proteínas Oncogénicas
/
Enterobactina
/
Lipocalinas
/
Lesión Renal Aguda
/
Hierro
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos