Acute toxicity of pinnatoxins E, F and G to mice.
Toxicon
; 60(6): 995-9, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-22813782
ABSTRACT
The acute toxicities to mice of pinnatoxins E, F and G, members of the cyclic imine group of phycotoxins, by intraperitoneal injection and/or oral administration, have been determined. These substances were all very toxic by intraperitoneal injection, with LD(50) values between 12.7 and 57 µg/kg. Pinnatoxin E was much less toxic by oral administration than by intraperitoneal injection, but this was not the case for pinnatoxin F. The median lethal doses of the latter substance by gavage and by voluntary intake were only 2 and 4 times higher than that by injection. The high oral toxicity of pinnatoxin F raises concerns as to the possibility of adverse effects of this substance in shellfish consumers, although it should be noted that no toxic effects in humans have been recorded with pinnatoxins or with any other compound of the cyclic imine group.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Espiro
/
Alcaloides
Límite:
Animals
Idioma:
En
Revista:
Toxicon
Año:
2012
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda