[Investigation of the relationship between apolipoprotein gene polymorphism and hepatitis B virus infection in China].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
; 26(1): 28-30, 2012 Feb.
Article
en Zh
| MEDLINE
| ID: mdl-22919747
ABSTRACT
OBJECTIVE:
To explore the gene polymorphisms of ApoAI-75 Msp1, ApoB Msp1, ApoCIII Sst1, LRP5, and ApoE genotypes in two pairs of semi different modes of hepatitis B for HBV markers.METHODS:
The patients are divided into 9 groups. There were a total of 720 cases, 80 patients in each group, The patients was carried out by SnaPshot method (single-base multilocus micro-sequencing), and different genotypes of each locus were conducted by the method of sequencing in order to support the final evidence of the accuracy of test results.RESULTS:
There was association between gene polymorphisms of ApoAI-75Msp1 and ApoE and different modes of two pairs of semi-hepatitis B (P < 0.05), while there wasn't any association between gene polymorphisms of ApoB-Msp1, ApoCIII-Sst1, LRP5 and different modes of two pairs of semi-hepatitis B (P > 0.05).CONCLUSION:
The gene polymorphism of ApoAI-75Msp1 and ApoE was associated with the different modes of HBV markers.
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Base de datos:
MEDLINE
Asunto principal:
Apolipoproteínas
/
Polimorfismo Genético
/
Hepatitis B
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
Asunto de la revista:
VIROLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
China