A179L, a new viral Bcl2 homolog targeting Beclin 1 autophagy related protein.
Curr Mol Med
; 13(2): 305-16, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-23228131
ABSTRACT
Autophagy is a relevant cellular defense mechanism that directly eliminates intracellular pathogens and has a crucial role for innate and adaptive immune responses. Some viruses have developed tools to counteract this cellular response. A179L, the viral Bcl2 homolog of African swine fever virus, interacts with proapoptotic Bcl2 family proteins to inhibit apoptosis. Here we report that this gene manipulates autophagy by interacting with Beclin 1 through its BH3 homology domain. At subcellular level, A179L colocalized with Beclin 1 at mitochondria and the endoplasmic reticulum. Virus infection inhibited autophagosome formation in cells; however, when autophagy was induced prior to or at the time of infection the number of infected cells was severely decreased.
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Base de datos:
MEDLINE
Asunto principal:
Fagosomas
/
Proteínas del Envoltorio Viral
/
Virus de la Fiebre Porcina Africana
/
Retículo Endoplásmico
/
Proteínas Reguladoras de la Apoptosis
/
Proteínas de la Membrana
/
Mitocondrias
Límite:
Animals
Idioma:
En
Revista:
Curr Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2013
Tipo del documento:
Article
País de afiliación:
España