Nocapyrones H-J, 3,6-disubstituted α-pyrones from the marine actinomycete Nocardiopsis sp. KMF-001.
Chem Pharm Bull (Tokyo)
; 61(5): 511-5, 2013.
Article
en En
| MEDLINE
| ID: mdl-23386029
ABSTRACT
Three new 3,6-disubstituted α-pyrones, nocapyrones H-J (1-3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2H-pyran-2-ones on the basis of UV, MS, NMR, and high resolution (HR)-FAB-MS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E(2) (PGE(2)) and interleukin-1ß (IL-1ß). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 µM in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Pironas
/
Nocardia
Límite:
Animals
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Año:
2013
Tipo del documento:
Article