Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems.
Macromol Biosci
; 13(5): 641-9, 2013 May.
Article
en En
| MEDLINE
| ID: mdl-23512337
ABSTRACT
A series of nanoparticles is prepared via layer-by-layer assembly of oppositely charged, synthetic biocompatible polyamidoamine polymers as potential carriers. Particle size, surface charge and internal chain mobility are quantified as a function of the polymer type and number of layers. The effect of addition of surfactant is examined to simulate the effects of nanoparticle dissolution. The cyctotoxicity of these particles (in epithelia and murine cell lines) are orders of magnitude lower than polyethyleneimine controls. Stable nanoparticles may be prepared from mixtures of strongly, oppositely charged polymers, but less successfully from weakly charged polymers, and, given their acceptable toxicity characteristics, such modularly designed constructs show promise for drug and gene delivery.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Poliaminas
/
Sistemas de Liberación de Medicamentos
/
Técnicas de Transferencia de Gen
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Nanopartículas
Límite:
Animals
Idioma:
En
Revista:
Macromol Biosci
Asunto de la revista:
BIOQUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido