In vitro chemo-sensitivity assay guided chemotherapy is associated with prolonged overall survival in cancer patients.
Pol Przegl Chir
; 85(6): 340-7, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23828416
ABSTRACT
THE AIM OF THE STUDY The overall survival (OS) of patients suffering From various tumour entities was correlated with the results of in vitro-chemosensitivity assay (CSA) of the in vivo applied drugs. MATERIAL AND METHODS:
Tumour specimen (n=611) were dissected in 514 patients and incubated for primary tumour cell culture. The histocytological regression assay was performed 5 days after adding chemotherapeutic substances to the cell cultures. n=329 patients undergoing chemotherapy were included in the in vitro/in vivo associations. OS was assessed and in vitro response groups compared using survival analysis. Furthermore Cox-regression analysis was performed on OS including CSA, age, TNM classification and treatment course.RESULTS:
The growth rate of the primary was 73-96% depending on tumour entity. The in-vitro response rate varied with histology and drugs (e.g. 8-18% for methotrexate and 33-83% for epirubicine). OS was significantly prolonged for patients treated with in vitro effective drugs compared to empiric therapy (log-rank-test, p=0.0435). Cox-regression revealed that application of in vitro effective drugs, residual tumour and postoperative radiotherapy determined the death risk independently.CONCLUSIONS:
When patients were treated with drugs effective in our CSA, OS was significantly prolonged compared to empiric therapy. CSA guided chemotherapy should be compared to empiric treatment by a prospective randomized trial.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sarcoma
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Neoplasias Cutáneas
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Neoplasias de la Mama
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Ensayos de Selección de Medicamentos Antitumorales
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Protocolos de Quimioterapia Combinada Antineoplásica
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Neoplasias del Sistema Digestivo
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Melanoma
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Pol Przegl Chir
Año:
2013
Tipo del documento:
Article